Without exiting the train station, find the underground metro Line C (Red Line) and take two stops to I.P. Pavlova. From the platform at I.P. Pavlova, take the escalators up, pass through the metro entrance/exit, head straight and take the last right up the escalators to street-level. Take any tram going right and down the hill two stops and get off at Karlovo náměstí. Walk alongside the tram-tracks heading right and walk to the end of the block. Take a left onto Odborů street (beside the Sony store) and MOSAIC HOUSE is approximately 50m down the street on your left, Odborů 4.
Or take a different route through Jindřišská.
Exit the train station and walk through the park, cross the street and make a right to Jeruzalémská, walk down the street (pass a synagogue). Get on tram number 14 in the direction of Sídliště Barrandov (tram goes through Wenceslas Square). Get off at Myslíkova (4 stops) and cross the street. Around the corner you will see MOSAIC HOUSE (address Odborů 4).